Leukoscan [sulesomab-monoclonal antibody] scintigraphy in infectious bone and joint diseases

When clinical data are insufficient to diagnose infrction of bone or joints, nuclear scanning becomes crucial in making an accurate diagnosis. The efficiency of' technetium-99m antigranulocyte monoclonal antibody Fob fragment [leukoscan] was evaluated in 66 patients with suspected muscloskeletal infection and was compared with technetium- 99m methylene diphosphonate bone scan in 54 patients. The overall sensitivity of leukoscan and MDP bone scan was 94.4% and 86.5% respectively Specificity was 91.6% and 50% respectively, and accuracy was 94% and 85% respectively. Leukoscan is more accurate in detecting bone and joint infection with better sensitivity and specificity compared with MDP bone scan